De La Salle offers students many extra-curricular activities. Students are encouraged to become involved in one or more of these activities and also encouraged to support all De La Salle activities by their presence and participation.
- Anime Club
- Architecture, Construction, and Engineering Mentors (ACE)
- Art Club
- Band
- Book Club
- Bowling Club
- Campus Ministry
- Cavalettes
- Cavalier Crafters
- Cheerleading
- Chess Club
- Chorus
- Color Guard
- Disney Club
- Ecology Club (ECO)
- French Club
- Gaming Club
- International Club
- La Troupe De La Salle
- No Place for Hate Club
- Pro-life Club
- Retreat Team
- Service Club
- Shakespeare Club
- Spanish Club
- String Orchestra
- Student Council
Honor Societies
- French National Honor Society
- Junior Classical League
- Mu Alpha Theta (Math Honor Society)
- National English Honor Society
- National Honor Society/Squires
- National Science Honor Society
- National Spanish Honor Society
- Quill and Scroll
- Rho Kappa (National Social Studies Honor Society)
- Tri-M (National Music Honor Society)